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--- John Casler <bioforce.inc@
> John Casler writes:
>
> Hi Ralph,
>
> I too claim no "insight" into the DIRECT hormonal
> relationship between
> Prostate problems, and Testosterone, but wonder at
> the evidence, or the
> interpretation of it.
>
> If the aromatized DHT was "THE" culprit, it seems
> strange that it occurs at
> a time in one's life where the levels are the
> lowest, compared to the ages
> of say 18 when they are the highest.
>
> It would seem then, that it is likely a more complex
> inter-relationship of
> sensitivities, balances, exposures, genetic markers
> or keys, and such.
>
> While it cannot be denied that DHT is an anabolic
> enabler to what might seem
> a "more" sensitive cellular proliferation of cancer
> cells, it might not be
> "THE" cause. Much like gasoline certainly will make
> a fire flare up, but it
> may not be the cause of the fire.
>
> I would assume that at some point in the exploration
> to understand diabetes,
> that some thought it was generally caused by too
> little insulin, which we
> now know is not always the case.
>
> As we also know, the relationship, profile, and
> production of the endogenous
> hormones changes as we age. Many are exploring that
> "relationship" as well
> as the related elements like cellular sensitivities
> to various hormonal
> levels. Much evidence for many diseases of aging
> seem to stem from the
> various reactive adjustments to these variations,
> and the inflammation that
> seems to accompany them.
>
> Any thoughts?
>
>
> Regards,
>
> John Casler
> TRI-VECTOR 3-D Force Systems
> Century City, CA
>
I don't think that any one is saying that testosterone
or DHT are the causes of prostate cancer but rather
their presence sort of feeds the fire.
In women their are types of breast cancer which are
very hormone sensitive. That is one of the reasons for
caution when using HRT in menopause.
We know that when prostate cancer occurs in younger
men (40+) it is significantly more aggressive than
when it occurs in older men (60+). In older men
prostate cancer is definitely slower growing and in
many cases the treatment of choice is to watch and
wait and do nothing since the prostate cancer is not
likely to cause problems.
The risk for older men taking testosterone supplements
is that they may turn what would otherwise be an
indolent cancer into an aggressive cancer.
You are correct in your statement that the issue is
very complex as to cause and effect, prevention etc.
I tried to summarize the highlights of a very
detailed and long chapter on prostate cancer in which
hormone was just one aspect of the discussion. I
highlighted what I thought was germane to the present
discussion.
Ralph Giarnella MD
Southington Ct USA
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