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"Our study provides insight into how chronic stress triggers long-
lived changes in the brain"
"We have shown that silencer molecules turned off a gene for a key
protein in the brain's hippocampus"
"The gene expression changes due to long-lasting modifications in
histones, proteins that regulate the turning on-and-off of genes via
a process called methylation. Methyl groups, the silencer molecules,
attach themselves to the histones, turning off the gene".
BDNF (derived neurotrophic factor)in the hippocampus has been linked
to memory, learning and depression, but Nestler said social defeat
stress probably similarly affects other genes there as well.
"The molecular scar induced by chronic stress in the hippocampus, and
perhaps elsewhere in the brain, can't be easily reversed," said
Nestler.
"To really cure depression, we probably need to find new treatments
that can remove the silencer molecules."
Eric Nestler, M.D., The University of Texas Southwestern Medical
Center - Nature Neuroscience February 26, 2006.
> Could we go back and check the physical causes for depression?
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