Stephen Scherer, Ph.D., of the Hospital for Sick Children, and
colleagues found that structural variation of genetic material is
widespread among those with autism.
The variations include gains and losses of genetic material, as well
as translocations and inversions, they reported in the February issue
of the American Journal of Human Genetics.
All told, Dr. Scherer and colleagues identified 13 genetic regions
with overlapping or recurrent chromosomal changes in 427 unrelated
people with autism that were not seen in healthy controls.
The "most compelling result" was a copy number variation on
chromosome 16 that was seen in 1% of the autism patients but not in
healthy controls, the researchers said.
http://www.medpaget
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